![]() ![]() This combination was approved for short-term treatment of musculoskeletal pain in India in 2010. 7 One of these combinations is 500 mg of chlorzoxazone and 400 mg of ibuprofen. 6 Thus, an ideal fixed-dose combination (FDC) is highly desirable as it is possible to reduce the analgesic and anti-inflammatory therapy timing by combining analgesic with a muscle relaxant. However, the European Medical Agency’s Committee on medicinal products for human use states that both selective and non-selective NSAIDs should be used in the lowest effective doses with the shortest possible duration of treatment sufficient to control the symptoms of the disease to minimize the risk of developing cardiovascular disease. 5įor higher efficacy, high doses of muscle relaxants and NSAIDs are required. Baclofen is used to relieve the spasms, cramping, and tightness of muscles by relaxing skeletal muscles in the body. ![]() In addition, many joint diseases are associated with muscle spasms therefore, adding anti-muscle contraction (skeletal muscle relaxant) like baclofen could relieve patients’ musculoskeletal pain. ![]() 3, 4 Oral non-steroidal anti-inflammatory drugs have been associated with greater efficacy in the more severe knee and hip OA patients. Around 18% of women and 10% of men over 60 years are affected by osteoarthritis (OA), 1, 2 which is a musculoskeletal condition characterized by severe deterioration and loss of articular cartilage and usually accompanied by structural and functional changes in the whole joint. ![]()
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